The University traces its origins to the Major Seminary of Popayán, founded between 1609 and 1617. It was a leading educational institution during the colonial period, operating in the San José Cloister, where the most innovative philosophical, political, and scientific ideas of the Enlightenment, the Age of Enlightenment of the eighteenth century, had a profound influence.

It was there that the generation who would later lead the struggle for independence from the Spanish Empire was educated. This generation included figures such as Francisco José de Caldas, Camilo Torres, Francisco Antonio Zea, José María Cabal, Joaquín de Caycedo y Cuero, and Francisco Antonio Ulloa, statesmen, scholars, and public servants. A significant part of the intellectual foundation of Colombia’s republican and independent life was shaped at the University of Cauca. Consequently, the history of Colombia’s independence and its emergence as an independent republic is closely intertwined with the history of the University.

In keeping with that tradition, the University of Cauca continues to be an institution dedicated to knowledge, progress, and the free exchange of ideas concerning the challenges and opportunities of social life. It remains committed to defending Colombia’s democratic values while consistently promoting freedom of expression and citizen participation. Over the past decade, it has also distinguished itself through the dynamism and growth of its research structure.